Cocrystals are defined as multi-component crystalline forms of defined stoichiometry stabilised by non-bonded interactions, usually H-bonding and lipophilic interactions. They are distinguished from salts in that no proton transfer occurs. Hydrates and solvates are closely related to cocrystals in that the interactions are similar. If sufficiently stable, hydrates may be considered viable forms, solvates are not usually developed, toxicity of the solvent and instability to drying are considerable barriers to progression.
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